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The SPHERE laboratory (methodS for Patients-centered outcomes and HEalth REsearch, INSERM UMR 1246, Nantes University, Tours University) and the company IDBC (A2com group) decided to create the Joint Laboratory RISCA (Research in Informatics and Statistics for Cohort-based Analyses).


  • To develop and  tocommercialize Plug-Stat®: a personalized software for the analysis of cohort-based data.
  • To improve the transfer of the research in Biostatistic from the SPHERE laboratory to the applications in clinical research.


Overall budget of 600K€ over 5 years, half financed by the French National Research Agency.

Cohorts associated with the project

  • DIVAT (French cohort in kidney transplantation)
  • EKITE (French cohort in kidney transplantation)
  • EVALADD (Cohort of patients with behavioral addictions in Nantes Hospital)
  • CORDABASE (Cohort of patients with aortic biologic valve replacement)
  • ATLANREA (Multicenric cohort of patients in ICU in the west of France )


The LabCom RISCA gathers together Biostaticians and Informaticians to develop the Plug-Stat® software.